Inhalation administration is the primary method of drug delivery to patients with pulmonary or airway disease. It is the primary route of accidental exposure during the manufacture, handling, or use of chemicals and agrochemicals. Testing the effects of inhaled substances successfully demands experience and competence in the safety evaluation of inhalation toxicology.
The treatment of cardiovascular disorders (coronary heart disease, angina pectoris, etc), cerebrovascular diseases (stroke, cerebral infarction, some pain, etc), and endocrine diseases (diabetes, etc) all benefit from non-invasive and painless inhalation drug delivery. Drugs that are breathed present numerous difficulties for preclinical animal studies because of the unusual method of administration.
Special laboratory apparatus is needed for the preclinical effectiveness, pharmacokinetic, and safety evaluation of inhaled formulations. To successfully demonstrate the effectiveness of these formulations, Alfa Chemistry has a dedicated team that offers inhalation toxicity testing and related services.
Studies include a number of topics, including acute, subchronic, chronic, and carcinogenicity. We specialize in unique inhalation toxicology endpoints (neonatal, reproductive, neurotoxicology, safety pharmacology) and are experienced in conducting radiolabeled aerosol disposition studies. We also have experience with radiolabeled aerosol disposition studies. In addition to pharmacokinetic samples, bronchoalveolar lavage, respiratory and cardiologic evaluations, and efficacy studies of medications, we provide a range of physiologic tests.
Research Capabilities
Inhalation toxicology studies are conducted in vitro or in vivo to assess the potential toxicity of materials that will/may be inhaled. Alfa Chemistry has a complete suite of inhalation drug delivery techniques, including intratracheal nebulization administration, and oral and nasal exposure administration.
- Experimental animal species: rats, mice, guinea pigs, dogs, and monkeys.
- 56 days of long-term dosing operation.
- Long-term dosing of 4 hours, which meets the OECD dosing time requirements.
- Powder and liquid drug aerosol generation system for powder and liquid dosing.
- Pulmonary dosing for nebulized drug delivery. Accurate and quantitative aerosolization of liquid samples directly into aerosols in the animal's trachea for aerosol lung administration.
- Oral and nasal contact dynamic inhalation poisoning.
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